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KMID : 0811720020060000167
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Korean Journal of Physiology & Pharmacology
2002 Volume.6 No. 0 p.167 ~ p.0
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Dependence of Rat Hippocampal c-Fos Expression on Intensity and Duration of Exercise
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Lee Taeck-Hyun
Jang Mi-Hyeon
Shin Min-Chul
Lim Baek-Vin
Kim Young-Pyo
Kim Hong
Shin Mal-Soon
Choi Hyun-Hee
Lee Kwang-Sik
Kim Chang-Ju
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Abstract
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The expression of c-Fos, an immediately early gene, is a marker of neural activity. In the present study, the effect of treadmill exercise on c-Fos expression was investigated in various regions of the rat hippocampus via immunohistochemistry. The first part of the experiment was aimed at determining the dependence of c-Fos expression on the intensity of treadmill exercise. In most of the hippocampal regions studied, increasing c-Fos expression was observed with increasing exercise intensity. In the second part of the experiment, the dependence of c-Fos expression on the duration of treadmill exercise was investigated. The c-Fos expression induced by mild-intensity exercise increased until the 7th day of exercise and subsequently decreased. Results of the present study suggest that the effect of treadmill exercise on neuronal activity in the hippocampus is intensity- and duration- dependent.
Source: Korean Journal of Physiology & Pharmacology.2002 Oct;6(Suppl II):S113-S113
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KEYWORD
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treadmill exercise, c-Fos, exercise intensity, exercise duration, immunohistochemistry
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